Cardiac Remodeling or Ventricular Remodeling
Cardiac Remodeling or Ventricular remodeling is generally accepted as a determinant of the clinical course of heart failure (HF). It defines as genome expression resulting in molecular, cellular and interstitial changes and manifested clinically as changes in shape, structure, size, and function of the heart. Cardiac remodeling can happen as a result physiological remodelling or pathological remodeling (injury to the heart muscle) and from cardiac load or injury, cardiac remodeling is influenced by hemodynamic load, neurohormonal activation. Mostly the cardiac myocyte is the major cell involved in cardiac remodeling. Due to this, the Myocardial Necrosis (cell death) and disproportionate thinning of the heart occurs. Congenital Heart Disease, chronic hypertension, with intra-cardiac shunting, and valvular Heart Disease may also lead to remodelling.
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